PREGA-ASH-300 CAPSULES contain pregabalin 300 mg, a prescription medicine belonging to the gabapentinoid class. Pregabalin acts on specific calcium-channel subunits in the nervous system and is used for certain types of nerve pain and, where approved, as an adjunctive treatment for partial-onset seizures.
This medicine should be taken only under medical supervision. The appropriate dose depends on the condition being treated, kidney function, response to treatment and other individual factors.
Product Full Description
PREGA-ASH-300 CAPSULES contain pregabalin 300 mg, as stated on the supplied product packaging.
Pregabalin acts on the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system.
This action helps regulate the release of certain neurotransmitters involved in pain signalling and neuronal excitability.
Pregabalin is prescribed for selected neuropathic pain conditions and may be used alongside other medicines for certain seizure disorders, depending on local approvals.
The 300 mg strength may not be appropriate for every patient; dosing must be individualized, particularly for people with reduced kidney function.
Use PREGA-ASH-300 only as prescribed and follow the instructions provided by the treating healthcare professional.
Usage Instructions
Take PREGA-ASH-300 exactly as prescribed by your doctor.
Swallow the capsule whole with water. It can generally be taken with or without food unless your prescriber advises otherwise.
Follow the prescribed timing and frequency. Do not take extra capsules to compensate for a missed dose without professional advice.
Do not increase, reduce or stop the medicine abruptly on your own. Pregabalin is generally tapered gradually when discontinuation is required.
Inform your doctor about kidney problems, pregnancy, breastfeeding, or any history of medicine misuse before starting treatment.
Avoid driving or operating machinery until you know how the medicine affects your alertness and coordination.
Medicinal Advantages
Neuropathic pain management: May help relieve pain caused by nerve damage in conditions for which pregabalin is prescribed.
Diabetic nerve pain: May be prescribed for neuropathic pain associated with diabetes.
Postherpetic neuralgia: May be used for persistent nerve pain following shingles.
Seizure management: May be prescribed as an add-on treatment for certain partial-onset seizures, according to applicable prescribing guidance.
Targeted nervous-system action: Acts on alpha-2-delta subunits of voltage-gated calcium channels rather than directly activating GABA receptors.
The approved uses depend on the applicable local product information and the individual patient's clinical circumstances.
Mechanism of Action
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This modulates calcium-channel activity and can reduce the release of certain neurotransmitters involved in pain transmission and neuronal excitability.
Although pregabalin is structurally related to gamma-aminobutyric acid (GABA), it does not work by directly binding to GABA-A or GABA-B receptors. Its precise therapeutic mechanism is not completely understood.
Off-Label Uses
Pregabalin may sometimes be prescribed for conditions outside its locally approved product information. Such prescribing is considered off-label and should be determined by a qualified healthcare professional after evaluating the evidence, expected benefits and individual risks. Off-label use should not be treated as an established indication for every patient.
Expert Advice
Pregabalin 300 mg is a substantial dose and is not necessarily suitable as an initial dose for every condition.
Dose selection and adjustment are especially important in people with impaired kidney function because pregabalin is eliminated primarily through the kidneys.
Pregabalin can cause dizziness and sleepiness. Avoid alcohol and seek professional advice about sedating medicines, as combined effects can impair alertness and may affect breathing.
Do not stop regular treatment suddenly without medical advice; gradual dose reduction is generally recommended.
Pregabalin can be misused or cause physical dependence in some people. Use it only for the person for whom it was prescribed.
Precautions
Prescription-only use: Use PREGA-ASH-300 only under the supervision of a qualified healthcare professional.
Kidney function: Tell your doctor if you have kidney disease. The dose may need adjustment.
Alertness and driving: Do not drive or operate machinery if you feel dizzy, sleepy or less coordinated.
Breathing concerns: Tell your doctor about breathing disorders or use of opioid medicines, sleeping tablets or other sedatives, because the combination may increase the risk of respiratory depression.
Pregnancy and breastfeeding: Seek medical advice before use if pregnant, planning pregnancy or breastfeeding.
Gradual discontinuation: Do not stop the medicine abruptly without medical guidance; sudden discontinuation may cause withdrawal symptoms or worsen the condition being treated.
Allergic reactions: Do not take another dose and seek urgent medical care if you develop facial, lip, tongue or throat swelling or difficulty breathing.
Secure storage: Keep the capsules away from children and do not share the medicine with anyone else.
Storage Conditions
Store in a cool, dry place according to the package instructions.
Protect from excessive heat, moisture and direct sunlight.
Keep the capsules in their original packaging until use.
Keep out of reach of children and pets.
Do not use after the expiry date printed on the pack.
Frequently Asked Questions
1. What is PREGA-ASH-300 CAPSULES?
It is a capsule containing pregabalin 300 mg, a prescription medicine used for certain nerve-pain conditions and, in appropriate cases, as an add-on treatment for partial-onset seizures.
2. What is pregabalin 300 mg used for?
Depending on local approval and the prescription, pregabalin may be used for diabetic peripheral neuropathy, postherpetic neuralgia and other approved neuropathic pain conditions. It may also be used as adjunctive therapy for certain seizures.
3. How does PREGA-ASH-300 work?
Pregabalin binds to alpha-2-delta subunits of voltage-gated calcium channels and modulates the release of neurotransmitters involved in pain signalling and neuronal excitability.
